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Association Between Hypothyroidism and Takotsubo Cardiomyopathy: Analysis of Nationwide Inpatient Sample Database

[ Vol. 13 , Issue. 3 ]

Author(s):

Dominika M. Zoltowska*, Yashwant Agrawal, Sandeep Patri, Sourabh Aggarwal, Chandra S. Reddy, Nishtha Sareen, Jagadeesh Kumar Kalavakunta and Vishal Gupta   Pages 222 - 225 ( 4 )

Abstract:


Background: Takotsubo Cardiomyopathy (TC), also called transient left ventricular (LV) ballooning syndrome, resembles myocardial infarction and is characterized by LV dysfunction in the absence of coronary artery disease. Hypothesis described for TC has been an intense social stressor, pheochromocytoma, thyrotoxicosis among others. We performed this study to analyze the association of hypothyroidism with TC.

Methods: We queried the Nationwide Inpatient Sample which represents 20% of all the United States hospital data for our study. We identified TC and hypothyroidism through their respective ICD9. Codes for years 2006-2012. SAS 9.4 was used to perform a chi-square analysis to find any statistical significance and p < 0.05 used to determine statistical significance. Significant differences were identified using odds ratio (OR) estimates.

Results: A total of 19,713 cases with TC were identified of which 17,340 (87.96%) were females and 2,373 (12.04%) were males. 3,272 patients with TC had diagnosis of hypothyroidism. There is statistically significant evidence of an association between TC and hypothyroidism (OR 2.21 (95% CI: 2.11- 2.31); p<0.0001).

There is evidence of increased statistical significance of females having TC 5.24 (95% CI: 4.96-5.53; (p<0.0001)) compared to males, with an increased statistically significance of females with hypothyroidism having TC, OR 6.65 (95% CI: 5.57-7.93; p< 0.001) compared to males.

Conclusion: There is an increased association of hypothyroidism, especially hypothyroidism for females with TC.

Keywords:

Acute heart failure, female gender, hypothyroidism, Takotsubo cardiomyopathy, left ventricular, coronary artery disease.

Affiliation:

Department of Internal Medicine, Western Michigan University Homer Stryker School of Medicine, 300 Portage Street, Kalamazoo, MI 49007, Department of Cardiology, St. Joseph Mercy Oakland Hospital, 44405 Woodward Ave, Pontiac, MI 48341, Department of Internal Medicine, Western Michigan University Homer Stryker School of Medicine, 300 Portage Street, Kalamazoo, MI 49007, Departmen of Cardiology, University of Nebraska Medical Center, S 42nd St & Emile St, Omaha, NE 68198, Department of Cardiology, St. Joseph Mercy Oakland Hospital, 44405 Woodward Ave, Pontiac, MI 48341, Department of Cardiology, St. Joseph Mercy Oakland Hospital, 44405 Woodward Ave, Pontiac, MI 48341, Department of Cardiology, Michigan State University/Borgess Medical Center, 1521 Gull Rd, Kalamazoo, MI 49048, Department of Cardiology, Michigan State University/ Borgess Medical Center, 1521 Gull Rd, Kalamazoo, MI 49048

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