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Association Between Delayed Graft Function (DGF) Biomarkers and Long-term Outcomes After Living Donor Kidney Transplantation

[ Vol. 13 , Issue. 4 ]

Author(s):

Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar and Azadeh Eshraghi*   Pages 312 - 318 ( 7 )

Abstract:


Background and Objectives: The association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interleukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is an association between these postoperative biomarkers with important recipient outcomes beyond this time in livedonor transplants.

Methods: NGAL and IL-18 four and 24 hours were measured in live-donor kidney transplant recipients after transplantation. The relationships between changes in these markers with clinical outcomes as well as kidney function were examined at 1 month and 2 years. Moreover, the association between delayed graft function with clinical outcome and Serum Creatinine (SrCr) was evaluated during this period.

Results: The Mean age for kidney recipients was 23.9 years. Significant interaction was observed between uNGAL 24 hr (pvalue=0.01) and uIL-18 four and 24 hr after transplantation (pvalue=0.04, 0.03; respectively) with patients’ outcome after 1 month and changes in uNGAL with outcomes after 2 years (pvalue= 0.04).

Conclusion: Changes in urine NGAL postoperative are associated with worst outcomes, 2 years after kidney transplantation, suggesting its potential role in identifying patients that are at high risk for diminished allograft function, outcome and survival.

Keywords:

Delay Graft Function, interleukin 18, urine neutrophil gelatinase-associated lipocalin, kidney transplant, serum creatinine (SrCr), urine output (UO).

Affiliation:

Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Department of Statistics, Faculty of Mathematical Sciences, Shahid Beheshti University, Evin Tehran, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Kidney Disease Research Center (CKDRC), Shahid Beheshti University of Medical Sciences, Tehran, Department of Clinical Pharmacy, School of Pharmacy, Shohadaye-7 Tir Hospital, Iran University of Medical Sciences, Tehran

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