Submit Manuscript  

Article Details


Hair Loss Prevention by a Scalp Cooling Device in Early Breast Cancer Patients: The Poliambulanza Preliminary Experience

[ Vol. 14 , Issue. 1 ]

Author(s):

Tiziana Prochilo*, Alessandra Huscher, Federica Andreis, Mara Mirandola, Elisabetta Zaina, Barbara Pomentale, Chiara Pedrali, Laura Zanotti, Stefano Mutti and Alberto Zaniboni   Pages 66 - 71 ( 6 )

Abstract:


Background: The most effective agents in the treatment of breast cancer have a common side effect, the hair loss. Some studies reported a reduction of hair loss with the use of the scalp cooling device. Indeed, it decreases the drug accumulation in the hair follicles. We report our preliminary experience with a scalp cooling device in reducing chemotherapy-induced alopecia and related distress in breast cancer patients undergoing adjuvant chemotherapy.

Methods: Hair loss grading and treatment tolerability were evaluated during chemotherapy every 21 days and 3 weeks after the last cycle of chemotherapy via Dean’s scale by patients and operators and a comfort analogic scale by patients. We administered the Hospital Anxiety and Depression Scale questionnaire at the baseline and at the end of treatment to assess the distress related to chemotherapy- induced alopecia.

Results: Among the 46 patients identified, 27 accepted the device. The eligible chemotherapy regimens included docetaxel+cyclophosphamide (TC), doxorubicin+cyclophosphamide (AC) and paclitaxel (P) weekly+trastuzumab (T). 24 pts (89%) completed the treatment; 3 pts (11%) treated with AC prematurely interrupted use of the scalp-cooling device due to inefficacy. After the last cycle of chemotherapy, the number of patient who perceived a HL < grade 2 was 16 (59%). The hair retention reported by operators has been higher (78%). 81.5% of patients well tolerated the treatment.

Conclusion: In our study, the scalp-cooling device reduced chemotherapy-induced alopecia in taxane- based chemotherapy. Furthermore, it suggests a discordance in hair loss perception between patients and operators.

Keywords:

Anxiety, breast cancer, chemotherapy, distress, hair loss, scalp cooling.

Affiliation:

Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Radiotherapy, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Surgery Department, Fondazione Poliambulanza, Brescia, Medical Oncology Unit, Fondazione Poliambulanza, Brescia

Graphical Abstract:



Read Full-Text article